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Mechanism of Action of Topoisomerase Inhibitors


Topoisomerase inhibitors may act in a number of ways or bind at different sites on the protein. For example they may inhibit the ATPase activity of the enzyme, act as cleavage-complex stabilisers, intercalate in the DNA, or prevent the DNA binding.

We can perform different assays which will help to elucidate the mode of action of an inhibitor.

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