Internationally recognised specialists in DNA-modifying enzymes

Inspiralis empowers research institutes, pharmaceutical companies and biotechs to develop new therapeutics. We do this through the provision of :

Contract research services & support

Whether you are looking for new anti-infectives or anti-cancer compounds, we can help you screen novel compounds, evaluate the results of medicinal chemistry efforts, determine mode of action or evaluate the effect of mutations.

Our Services

Drug discovery products

We supply enzymes and assay kits to the pharmaceutical industry and academia to aid their drug discovery efforts. Unlike other suppliers, we provide the assay, substrate and buffer all together with simplified unit definitions, making our kits much easier to use.

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Biomanufacturing

We can provide any of our products in mass quantities as well as produce custom enzymes in bulk. Our dedication to excellence in biomanufacturing is evident in our unwavering commitment to quality, consistency, and affordability. We take pride in providing quality products with exceptional lot-to-lot consistency, ensuring that our clients receive the best value without compromising on quality.

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What our clients say...

We selected Inspiralis as our supplier because their product was far and away the highest quality, and excellent value. However, beyond their product quality and consistency, we found Inspiralis to be an incredibly communicative and collaborative partner - going above and beyond providing us data to enable our own process development, sourcing a boutique shipping company to ensure our high-dollar-value shipment arrived safely and still frozen, or working at all hours to produce an extra large, last-minute, and highly urgent request. I would very happily work with Inspiralis again in the future.

Manager of Operations and Planning A Gene Therapy Company, USA
The kDNA we purchased from Inspiralis is much better than the one from Inspiralis's competitors. We have noticed a significant improvement in stability and reproducibility of results when we started to use kDNA from Inspiralis. We have also performed super resolution microscopy and AFM on the kDNA and the integrity and purity of the samples are by far the best.

Davide Michieletto Royal Society University Research Fellow
What truly sets Inspiralis apart is their deep understanding of the research process and the needs of researchers. They are not merely suppliers but true research partners. Their team is consistently communicative, collaborative, and proactive, often going above and beyond to ensure our projects run smoothly.

I am thoroughly satisfied with their partnership and I will not hesitate to work with Inspiralis again in the future. Their speed, quality, and dedication to understanding our research needs have made all the difference. We have published more than 20 papers on bacterial gyrase and human Topoisomerase, and Inspiralis' expertise was an important factor in our success, highlighting their commitment to advancing scientific knowledge.

Prof. Dr. Janez Ilaš Professor of Medicinal Chemistry - University of Ljubljana, Faculty of Pharmacy

Bespoke services as your research partner

Our team can provide assays, mechanistic studies and develop custom proteins for your specific research needs. Whether you are looking for new anti-infectives or anti-cancer compounds, we can help you screen novel compounds, evaluate the results of medicinal chemistry efforts, determine mode of action or evaluate the effect of mutations. Alternatively, if you need further target enzymes expressed and purified, we may be able to help.

Contract Research Services

Enzymes, substrates and assay kits

We supply enzymes and assay kits to the pharmaceutical industry and academia to aid research into anti-infectives, anti-cancer and other drugs. Our kits are easy to use as we provide the assay, substrate and buffer all together with simplified unit definitions, unlike other suppliers. All of our enzymes can also be supplied in large or bulk quantities or at higher concentrations.

Signature products

Discover our latest high-performance enzymes and substrates

T3 DNA Ligase

Now available in Catalogue

T3 DNA Ligase for liagtion of short and xeno-oligonucleotides. Also available in large volumes.
Biscat DNA

New Decatenation Substrate

BisCat is a revolutionary new singly-catenated plasmid substrate that has many advantages over kDNA!
Zika virus NS2B-NS3 Protease Assay Kit

New Assay Kit

Polyprotein processing protease enzymes from Flaviviridae group are considered important drug targets. Zika virus NS2B-NS3 protease recognises a specific amino acid sequence valine-lysine-lysine-arginine.
TDP2 Assay Kit

New Assay Kit

This enzyme resolves TOP2 cleavage complexes and is a potential target for anti-cancer compounds. Our fluorescent assay is plate-based allowing for higher throughput.
Anti-Human Topo IIα Polyclonal Antibodies

New in Antibodies

New Human Topo II isoform-specific polyclonal antibodies for Western blotting and immunofluorescence.

RUO and GMP-compliant bulk products

Inspiralis is here to provide tailored, high-quality bulk products in both RUO and GMP-compliant grades that will help you achieve your objectives. Whether you are looking for bulk enzyme products for your DNA-Encoded Libraries, or enzymes for non-viral gene therapy products, contact us to explore how we can support your requirements and propel your projects forward.

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Responsive, collaborative expertise

Inspiralis empowers early adopter drug discovery and pre-clinical research utilising DNA modifying enzymes. Our directors and scientific staff have impressive publication records and many years of in-depth experience in the field of gene-modifying enzymes. They combine the provision of Inspiralis’ high-quality products with personalised technical support, ensuring that optimal results are achieved using Inspiralis’ products and services.

Our expertise in DNA topoisomerases and DNA topology are unmatched and we have the widest range of DNA topoisomerases available worldwide.

As a collaborative and responsive partner, we work closely with our clients to understand their specific needs and goals, delivering personalised solutions that exceed expectations.

Contact Us About Collaborating