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Drug-Resistant Eukaryotic Topoisomerase Enzymes

We offer various Human topoisomerase II mutants. We have more than 25 mutants in different topoisomerases (see our range of Drug-Resistant Bacterial Topoisomerases) and we can make other mutants as requested. For the currently available mutants please see the table below:

Organism Mutation
Topo II Alpha K378A
Topo II Beta A485P
Topo II Alpha Amino acids 1-453

Please contact us directly for more information or to request pricing!

We have a range of products that will help your drug discovery efforts, whether you are looking for novel anti-infectives, or new anti-cancer compounds, we have a range of target enzymes, available with and without their substrates, in easy to use kits. We also supply different topological isoforms of our DNA substrates.

Don't see your required enzyme? Contact us to see if we can make it for you or visit our Custom Proteins page! 

Not doing drug discovery? Our enzymes and DNA substrates are of extremely high purity and quality, perfect for reliable results!

All of our enzymes can be supplied in large or bulk quantities or at higher concentrations. Please contact us for a quote!

Likewise, if you require enzymes with particular specifications (e.g. low endotoxin, DNase or RNase free, low bioburden etc.), please contact us.


You can contact us on +44(0) 1603 673590 or +44(0) 1603 673591, at [email protected] or by visiting our contact us page to discuss your requirements.

Need help?
Call us on +44 (0) 1603 673591
Email on [email protected]

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