Activity: DNA gyrase and topo IV inhibitors. Inhibit the hydrolysis of ATP by binding as a site overlapping the ATP-binding site, acting as competetive inhibitors.
Source: Naturally occuring products of Streptomyces species
Formula: C31H36N2O11 M. Wt.: 612.6 g/mol
Solubility: Soluble in water, ethanol and DMSO (all at 100 mg/ml).
Formula: C35H37N2O11Cl M. Wt.: 697.1 g/mol
Solubility: Insoluble in water, poorly soluble in ethanol (1 mg/ml) and soluble in DMSO (> 100 mg/ml).
Formula: C55H59N5O20 M. Wt.: 1109.4 g/mol
Activity: DNA gyrase and topo IV inhibitors. Interfere with DNA chain breakage and reunion.
Source: Synthetic compounds.
Formula: C12H12N2O3 M. Wt.: 232.2 g/mol
Solubility: Soluble in water (100 mg/ml).
Formula: C17H18N3O3F M. Wt.: 331.3 g/mol
Solubility: Soluble in water (> 30 mg/ml), soluble in ethanol (< 10 mg/ml) and DMSO (< 10 mg/ml).
Activity: DNA gyrase inhibitors. Inhibits early stage of catalytic cycle, inhibiting binding of DNA to enzyme.
Source: Streptomyces antibioticus
Formula: C46H42NO18Cl M. Wt.: 932.3 g/mol
Solubility: Poorly soluble in water, soluble in DMSO (10 mg/ml).