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List of publications

Aubry, A., Pan, X-S., Fisher, L.M., Jarlier, V. and Cambau, E. (2004). Mycobacterium tuberculosis DNA Gyrase: Interaction with Quinolones and Correlation with Antimycobacterial Drug Activity. Antimicrob. Agents Chemother.48(4), 1281- 1288. PubMed ID: 15047530

Flatman, R.H., Howells, A.J., Heide, L., Fiedler, H.-P. and Maxwell, A. (2005). Simocyclinone D8: an inhibitor of DNA gyrase with a novel mode of action. Antimicrob. Agents Chemother.49, 1093-1100. PubMed: 15728908.

Galm, U., Heller, S., Shapiro, S., Malcolm Page, M., Shu-Ming Li, and Heide, L. (2004). Antimicrobial and DNA Gyrase-Inhibitory Activities of Novel Clorobiocin Derivatives Produced by Mutasynthesis. Antimicrob. Agents Chemother. 48(4),1307-1312. PubMed ID: 15047534

Gross C.H., Parsons J.D., Grossman T.H., Charifson P.S., Bellon S., Jernee J., Dwyer M., Chambers S.P., Markland W., Botfield M., Raybuck S.A. (2003). Active-site residues ofEscherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistance. Antimicrob. Agents Chemother47(3), 1037- 1046. PubMed ID: 12604539

Gruger, T., Nitiss, J.L., Maxwell, A., Zechiedrich, E.L., Heisig, P., Seeber, S., Pommier, Y. and Strumberg, D. (2004). A mutation in Escherichia coli DNA gyrase conferring quinolone resistance results in sensitivity to drugs targeting eukaryotic topoisomerase II. Antimicrob. Agents Chemother.48, 4495-4504. PubMed: 15561817

Heddle, J.G., Mitelheiser, S., Maxwell, A. and Thomson, N.H. (2004). Nucleotide binding to DNA gyrase causes loss of DNA wrap. J. Mol. Biol.337, 597-610. PubMed: 15019780

Li, K., Pasternak, C., Härtig, E., Haberzettl, K., Maxwell,A. and Klug, G (2004). Thioredoxin can influence gene expression by affecting gyrase activity. Nucleic Acids Res.32(15), 4563-4575. PubMed ID:15328368

Locher, H.H., Borer, Y., Gaertner, M., Schroeder, S., Specklin, J-L. and Hubschwerlen, C. (2002). Antibacterial Characterization and Mode of Action of New Oxazolidinone-Quinolone Hybrids. 42th ICAAC (2002), poster and abstract F-1317.

Macinga, D.R., Renick , P.J., Makin, K.M., Ellis, D.H., Kreiner, A.A., Min Li, Rupnik, K.J., Kincaid, E.M., Wallace, C.D., Ledoussal, B. and Morris, T.W. (2003). Unique Biological Properties and Molecular Mechanism of 5,6-Bridged Quinolones. Antimicrob. Agents Chemother. 47(8), 2526-2537. PubMed ID: 12878515

Morgan-Linell, S., K., Hiasa, H., Zechiedrich, L. and Nitiss, J., L. (2007). Assessing Sensitivity to Antibacterial Topoisomerase II Inhibitors. Current Protocols in Pharmacology. Supplement 39. 3.13.1-13.26

Oram, M. and Pato, M.L. (2004). Mu-Like Prophage Strong Gyrase Site Sequences: Analysis of Properties Required for Promoting Efficient Mu DNA Replication. J. Bact.186(14), 4575-4584. PubMed ID:15231790

Pacholec, M., Freel Meyers, C.L., Oberthu¨r, M., Kahne, D. and Walsh, C.T. (2005). Characterization of the Aminocoumarin Ligase SimL from the Simocyclinone Pathway and Tandem Incubation with NovM,P,N from the Novobiocin Pathway. Biochemistry44, 4949-4956. PubMed ID: 15779922

Reyes-Domínguez, Y., Contreras-Ferrat, G., Ramírez-Santos, J., Membrillo-Hernández, J. and Gómez-Eichelmann, M.C. (2003). Plasmid DNA Supercoiling and Gyrase Activity inEscherichia coli Wild-Type and rpoS Stationary-Phase Cells. J. Bact.185(3), 1097-1100. PubMed ID: 12533486

Rudolph J, Theis H, Hanke R, Endermann R, Johannsen L and Geschke F. (2001). seco-Cyclothialidines: new concise synthesis, inhibitory Gyrase activity toward bacterial and human DNA topoisomerases, and antibacterial properties. J. Med. Chem.44(4), 619-626. PubMed ID: 11170652

Strahilevitz, J. and Hooper, D.C. (2005). Dual Targeting of Topoisomerase IV and Gyrase To Reduce Mutant Selection: Direct Testing of the Paradigm by Using WCK-1734, a New Fluoroquinolone, and Ciprofloxacin. Antimicrob. Agents Chemother. 49(5), 1949-1956. PubMed ID: 15855518

Strumberg, D., Nitiss, J.L., Dong, J., Walker, J., Nicklaus, M.C., Kohn, K.W., Heddle, J.G., Maxwell, A., Seeber, S. and Pommier, Y. (2002). Importance of the fourth alpha-helix within the CAP homology domain of type II topoisomerase for DNA cleavage site recognition and quinolone action. Antimicrob. Agents Chemother.46, 2735-2746. PubMed: 12183223.

Wall, M.K., Mitchenall, L.A. and Maxwell, A. (2004). Arabidopsis thaliana DNA gyrase is targeted to chloroplasts and mitochondria. Proc. Natl. Acad. Sci. USA101, 7821-7826. PubMed: 15136745